Endocrine Abstracts

Macroprolactin is a high molecular mass prolactin isoform found in some normal individuals. The most common form of macroprolactin arises from binding of prolactin to IgG ('big-big' prolactin), with a molecular mass 150-170 kD. A further prolactin isoform of intermediate size ('big' prolactin, 50-60 kD), has also been described but the nature and significance of this form is less clearly understood.We have previously described the effects of pregnancy in...